added in Year 5
This project addresses the role of
testosterone and other androgens in protecting
the brain against degenerative insults.
1.
Gonadectomized
(GDX) and sham-GDX male rats will be evaluated for neuron loss following
kainate lesion to determine whether testosterone depletion increases
vulnerability to neuronal injury.
2.
Testosterone
replacement will be administered to gonadectomized male rats to evaluate its
ability to reduce neurodegeneration.
3.
The role
of estrogen will be assessed in testosterone neuroprotection using the in vivo
kainate lesion model.
4. The role of androgen receptors will be
assessed in testosterone
neuroprotection using the in vivo kainate lesion model
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Christian J Pike, Ph.D.
Estrogen Main | Project 1 | Project 2 | Project 3 | Project 4 | Publications